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门诊处方药物配伍中,若能合理联合用药,则起协同作用,提高治疗效果;若不合理配伍,则降低药效,或起相反作用而影响治疗。笔者从门诊处方配伍中发现以下几个问题应引起注意。一、四环素族抗生素:与制酸药如胃舒平、204胃药合用时,由于提高胃液的PH值,致使四环素族药物溶解度降低,而影响小肠吸收率。与铁剂或含钙、镁、铝、铋等离子的药物配伍,可形成四环素族络合物而影响其吸收。二、维生素类药物:维生素C与维生素K_3伍用时,产生氧化还原反应,应避免同用。维生素B_1与抗酸药并用,可使维生素B_1遭到破坏,不宜合用。
Outpatient prescription drug compatibility, if a reasonable combination of medication, then act synergistically to improve the treatment effect; if unreasonable compatibility, then reduce the efficacy, or the opposite effect and treatment. The author found out from the outpatient prescription compatibility should pay attention to the following questions. A tetracycline antibiotic: and antacids such as stomach Shuping, 204 stomach medicine, due to increase the PH value of gastric juice, tetracycline drugs resulting in reduced solubility, and affect the intestinal absorption rate. With iron or calcium, magnesium, aluminum, bismuth plasma drug compatibility, the formation of tetracycline complexes affect its absorption. Second, vitamin drugs: vitamin C and vitamin K_3 Wu use, produce redox reaction, should be avoided with the use. Vitamin B_1 and antacids and vitamin B_1 can be destroyed, should not be combined.