目的:研究血钠24h尿钠测定在颅脑损伤诊治的临床意义。方法:454例中发现血钠失衡232例,血钠为血清钠测定值,24h尿钠测定方法是采集24h尿液混匀后尿钠浓度×24h尿量=24h尿钠总量,再根据24h尿钠测定补液治疗为观察组,按常规及经验治疗为对照组,对2组病例的治疗结果比较分析。结果:两组治疗结果比较其当日血钠与前一日血钠差值均数,观察组小于对照组有明显差异(P<0.01),纠正所耗时间,观察组短于对照组有明显差异(P<0.01)。结论:结合血钠,24h尿钠测定的结果分析,对颅脑损伤病人合并血钠失衡的病因判定和治疗,特别是特殊类型的水、钠代谢紊乱病例的诊治,较常规补液治疗,提供了更为安全、准确、有效的方法。 Objective: To study the clinical significance of serum sodium 24h urinary sodium in diagnosis and treatment of craniocerebral injury. Methods: In 454 cases, 232 cases were found to have imbalance of serum sodium. Serum sodium was measured as serum sodium. 24h urine sodium concentration was measured by 24 hours after urine collection. Urinary sodium concentration 24h urine volume = Urinary sodium rehydration therapy for the observation group, according to conventional and empirical treatment for the control group, the treatment of two groups of patients were analyzed. Results: The results of the two groups were compared on the same day of sodium and serum sodium difference between the previous day, the observation group was smaller than the control group were significantly different (P <0.01), time-consuming correction, observation group shorter than the control group were significantly different (P <0.01). Conclusion: Based on the analysis of serum sodium and 24h urinary sodium, the etiology and treatment of patients with craniocerebral injury combined with serum sodium imbalance, especially the diagnosis and treatment of special types of water and sodium metabolic disorders, are provided more than conventional rehydration therapy More secure, accurate and effective way.