【摘 要】
：
利用溶剂蒸发法制备载有5-氟尿嘧啶(5-FU)可生物降解的聚乙丙交酯(PLGA)植入膜片,着重讨论了在降解过程中,聚合物的重均分子量(Mw)、数均分子量(Mn)和膜片的内部形态变化规律
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利用溶剂蒸发法制备载有5-氟尿嘧啶(5-FU)可生物降解的聚乙丙交酯(PLGA)植入膜片,着重讨论了在降解过程中,聚合物的重均分子量(Mw)、数均分子量(Mn)和膜片的内部形态变化规律.通过在PLGA膜片表面分别涂层ω=23%的凝胶溶液和PLGA(丙交酯:乙交酯=50:50,摩尔比)溶液对膜片进行改性,考察改性后的膜片对5-FU释放速率的影响规律.用零级释放和一级释放方程对5-FU释放曲线的各个阶段进行描述,通过非线性拟舍得到了相关的释放系数,并且提出5-FU的释放机理.结果表明:与未改性的膜片相比,涂有明胶的PLGA膜片5-FU首次释放率从50%降低到20%,释放曲线分为两个阶段,前阶段的药物释放由凝胶降解控制,后阶段为零级释放;膜片涂有PLGA后阻止了突然释放率,且两个阶段5-FU的释放曲线均符合零级释放.
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