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如何防治肝纤维化是目前备受关注的问题,活血化瘀类中药治疗肝纤维化有良好的效果。研究发现,虽然活血化瘀类中药有效组分结构相似性不高,但是理化性质比较相似。与实验阶段药物和中药数据库中全部活性成分相比,活血化瘀类中药有效组分的化学空间分布更接近已知药物,约90%的有效组分符合Lipinski五规则。基于靶点蛋白作用通路的研究发现,活血化瘀中药通过直接作用或间接影响纤维化相关蛋白,并且多靶点多通路协同作用于多条生物路径,直接抑制TNF或间接调控NF-kappaB是其中典型的两条途径。这些研究结果可为阐明活血化瘀类中药的作用机制提供更多信息,有助于进一步筛选抗肝纤维化作用药物。
How to prevent and treat hepatic fibrosis is the most concerned issue now. Chinese medicine for promoting blood circulation and removing blood stasis has a good effect on treating liver fibrosis. The study found that although the Chinese medicine effective components of blood circulation structure similarity is not high, but the physical and chemical properties are similar. Compared with all the active components in the experimental phase and traditional Chinese medicine database, the chemical spatial distribution of effective components of Chinese traditional medicine is closer to the known drugs, and about 90% of the effective components comply with Lipinski’s five rules. Based on the role of target protein pathway study found that traditional Chinese medicine promoting blood circulation through direct or indirect effects of fibrosis-related proteins and multi-target multi-pathway synergistic effect on a number of biological pathways, direct inhibition of TNF or indirect regulation of NF-kappaB is Two typical ways. These findings may provide more information for elucidating the mechanism of action of traditional Chinese medicine on promoting blood circulation and removing blood stasis, and help to further screen anti-liver fibrosis drugs.