作者对激素抗药性或激素依赖性并且环磷酰胺或苯丁酸氮芥治疗过,20例复发的肾病综合征患者,给与环孢菌素A口服治疗8周。环孢菌素A的开始剂量为7mg/kg/日,以后调整剂量使其血药浓度在用高性能液相色层分析法时达到100～200ng/ml水平。20例患者中,14例完全缓解,其余的6例其蛋白尿的程度也减轻。此14例治疗有效的患者的平均血清蛋白浓度,在环孢菌素A治疗后由2.1g/dl上升到4.1g/dl(P<0.00001)。此14例患者的平均血清胆固醇水平在环孢菌素A治疗后由 The authors treated steroid-resistant or hormone-dependent cyclophosphamide or chlorambucil in 20 patients with relapsed nephrotic syndrome orally for 8 weeks. The initial dose of cyclosporin A was 7 mg / kg / day, after which time the dose was adjusted so that its plasma concentration reached a level of 100-200 ng / ml when using high performance liquid chromatography. Of the 20 patients, 14 had complete remission and the remaining 6 had less proteinuria. Mean serum protein concentrations in these 14 therapeutically effective patients increased from 2.1 g / dl to 4.1 g / dl after cyclosporin A treatment (P <0.00001). The mean serum cholesterol levels in these 14 patients were determined after cyclosporine A treatment