系统性红斑狼疮激素治疗中发生的骨坏死,已有不少文献报告。本例不仅有多骨坏死还有骨膜增厚,在文献上尚未见到报告,也是骨坏死机制难以解释的,特报告于下。患者朱××,女,31岁。住院号22075。1974年4月因面颊和颈部红斑,伴发烧及关节痛1周而住院。住院前曾在他院血中查到狼疮细胞。查体:二面颊蝶形红斑、颈部及上胸部散在性红斑。心率105/分,律齐,心尖Ⅱ级SM。体温40℃,血沉50mm/小时、抗“O”2500单位。心电图正常。血常规:血红蛋白11克%、红细胞300万/立方毫米。白细胞3000/立方毫米、中性61%、淋巴38%、酸性1%。确诊为系 There have been many reports of osteonecrosis in systemic lupus erythematosus hormone therapy. In this case, there are not only multiple osteonecrosis but also periosteal thickening, which have not been reported in the literature, and the mechanism of osteonecrosis is hard to explain. Zhu × × patients, female, 31 years old. Hospital number 22075. 1974 April due to cheek and neck erythema, with fever and arthralgia for 1 week and hospitalization. Lupus cells were found in the blood of his hospital before hospitalization. Physical examination: two cheek butterfly erythema, neck and upper chest scattered erythema. Heart rate 105 / min, Law Qi, apex Ⅱ SM. Body temperature 40 ℃, ESR 50mm / h, anti-“O” 2500 units. Normal ECG. Blood: hemoglobin 11%, erythrocytes 3000000 / cubic millimeter. WBC 3000 / cubic mm, 61% neutral, lymph 38%, acid 1%. Confirmed as Department