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目的:观察在中西医常规治疗上联合氟哌噻吨美利曲辛对功能性消化不良上腹痛综合征临床疗效。方法:将120例患者根据治疗方法不同分为2组。对照组给予中西医常规治疗;观察组在中西医常规治疗基础上加用氟哌噻吨美利曲辛治疗。比较2组患者临床疗效、临床症状评分、汉密尔顿抑郁量表(HAMD)、抑郁自评量表(SDS)、焦虑情绪评分(HAMA)、焦虑自评量表(SAS)。结果:总有效率观察组91.67%,对照组76.67%,2组比较,差异有显著性意义(P<0.05)。2组治疗后与治疗前比较,临床常见症状均有改善,差异有显著性意义(P<0.05);治疗后,观察组腹痛、腹胀、反酸、嗳气评分明显低于对照组(P<0.05)。2组治疗后与治疗前比较,各项评分均有缓解,差异有显著性意义(P<0.05);治疗后,观察组HAMA评分、HAMD评分、SAS评分、SDS评分均明显低于对照组(P<0.05)。结论:功能性消化不良上腹痛综合征患者加用氟哌噻吨美利曲辛治疗有助于改善临床症状、缓解负面情绪,提高治疗效果。
Objective: To observe the clinical curative effect of combination therapy with flupenthixol and melitracen on functional dyspepsia and upper abdominal pain syndrome in traditional Chinese and Western medicine. Methods: 120 patients were divided into two groups according to different treatment methods. The control group was given routine treatment of Chinese and Western medicine; the observation group was treated with flupentixol and melitracen on the basis of the traditional Chinese and Western medicine. The clinical efficacy, clinical symptom score, Hamilton Depression Rating Scale (HAMD), Depression Scale for Self Assessment of Scrutiny (SDS), Hyperactivity Awareness Scale (HAMA) and Self-rating Anxiety Scale (SAS) were compared between the two groups. Results: The total effective rate was 91.67% in the observation group and 76.67% in the control group. There was significant difference between the two groups (P <0.05). After treatment, the common symptoms in both groups were improved after treatment, with significant difference (P <0.05). After treatment, the scores of abdominal pain, bloating, acid reflux and belching in observation group were significantly lower than those in control group (P <0.05) ). The scores of HAMA, HAMD, SAS and SDS in the observation group were significantly lower than those in the control group after treatment (P <0.05) P <0.05). Conclusion: Patients with functional dyspepsia and upper abdominal pain syndrome plus flupentixol and melitracen can improve clinical symptoms, relieve negative emotions and improve the therapeutic effect.