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给高脂血症鹌鹑连续灌胃（ig）西红花总甙7周,能明显抑制由高脂饮食所致的血清TC,TG,LDL-C,VLDL-C和AI的升高,防止HDL,HDL2-C及HDL3-C的降低并可提高HDL-C／TC及HDL3-C／HDL3-C值。给药组动物动脉壁TC,TG及CE含量,CE／TC值和MDA值均较高脂对照组明显降低,从而减少胆固醇及胆固醇酯在鹌鹑动脉壁中的沉积,降低脂质过氧化物对血管内皮细胞的损伤。而且西红花总甙可减轻高脂饲料所致动脉粥样硬化斑块的形成和肝系数的升高。病理切片表明,该药还能对抗因高脂饲料所造成冠状动脉血管壁增厚、管腔变小及肝组织脂肪变性。
Continuous administration of hyperlipidemic sputum (ig) to total saffron for 7 weeks can significantly inhibit the increase of serum TC, TG, LDL-C, VLDL-C and AI caused by high-fat diet, and prevent HDL , HDL2-C and HDL3-C decrease and increase HDL-C/TC and HDL3-C/HDL3-C values. The TC, TG and CE contents, CE/TC values and MDA values in the arterial wall of the animals in the administration group were significantly lower in the control group, which reduced the deposition of cholesterol and cholesteryl esters in the iliac artery wall, and decreased the lipid peroxide level. Vascular endothelial cell damage. Moreover, total saffron can reduce atherosclerotic plaque formation and hepatic coefficient increase in high-fat diets. Pathological sections showed that the drug can also counteract the coronary vascular wall thickening, lumen shrinkage, and hepatic steatosis caused by high-fat diets.