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目的:探究解毒胶囊对乳腺增生大鼠乳腺组织中P16、P53表达的影响。方法:选取SD雌性未孕12周龄大鼠50只,随机分为正常组、模型组、方药组、三苯氧胺组、乳癖消组5组,每组各10只。药物治疗4周后检测各组大鼠乳腺组织P16和P53表达情况。结果:模型组较正常组比较,P16和P53呈现高表达,其差异有统计学意义;药物治疗后的3组大鼠P16和P53表达均减弱,其中方药组及三苯氧胺组比乳癖消组减弱明显,其结果有统计学意义(P<0.01,P<0.05);而方药组与三苯氧胺组差异无统计学意义(P>0.05)。结论:解毒胶囊能够干预乳腺增生大鼠的乳腺组织P16和P53的表达情况,对乳腺增生大鼠有调节和治疗作用。
Objective: To investigate the effect of Jiedu capsule on the expression of P16 and P53 in mammary gland tissue of rats with hyperplasia of mammary glands. Methods: Fifty SD female non-pregnant 12-week-old rats were randomly divided into normal group, model group, prescription group, tamoxifen group and Rupixiao group. Four weeks after the drug treatment, the expression of P16 and P53 in each group was detected. Results: The expression of P16 and P53 in the model group was higher than that in the normal group, and the difference was statistically significant. The expression of P16 and P53 in the three groups were weakened after the drug treatment, in which the prescription group and the tamoxifen group were weaker than those of the Rupixiao group Obviously, the results were statistically significant (P <0.01, P <0.05), while the prescription group and the tamoxifen group no significant difference (P> 0.05). Conclusion: Jiedu capsule can intervene the expression of P16 and P53 in mammary gland hyperplasia rats and regulate and treat mammary gland hyperplasia rats.