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目的对梅毒和系统性红斑狼疮(SLE)患者血清中抗心磷脂(ACL)抗体的反应强度以及类型进行比较研究。方法应用ELISA法对99例梅毒和75例SLE患者的血清中ACL抗体的反应强度以及ACL抗体的IgG与IgM类型进行检测。结果SLE和梅毒患者血清中IgG型ACL抗体阳性率分别为48.00%和40.40%;梅毒的阳性血清反应强度高于SLE患者(P<0.001);IgM型ACL抗体的阳性率在SLE和梅毒患者中分别为18.67%和61.62%,梅毒的ACL抗体阳性率显著高于SLE患者(P<0.001),且梅毒患者IgM型ACL抗体阳性血清反应强度高于SLE患者(P<0.005)。结论这种ACL抗体IgG、IgM阳性率与反应强度的差异,反映了SLE患者和梅毒患者产生ACL抗体的机理与功能有所不同。
Objective To compare the intensity and type of anti-cardiolipin (ACL) antibody in serum of patients with syphilis and systemic lupus erythematosus (SLE). Methods The serum levels of ACL antibodies in 99 syphilis and 75 patients with SLE and the IgG and IgM types of ACL antibody were detected by ELISA. Results The positive rates of IgG-type ACL antibody in sera of patients with SLE and syphilis were 48.00% and 40.40%, respectively. The positive serum reaction of syphilis was higher than that of patients with SLE (P <0.001). The positive rate of IgM-type ACL antibody in patients with SLE and syphilis (18.67% and 61.62% respectively). The positive rate of ACL antibody in syphilis was significantly higher than that in SLE patients (P <0.001). The positive serum IgM antibody levels in syphilis patients were higher than those in SLE patients (P <0.005). Conclusions The differences in the positive rates of IgG and IgM of ACL antibodies and their reaction intensities reflect the differences in the mechanism and function of ACL antibodies produced by patients with SLE and syphilis.