症状和体征是临床用于诊断、鉴别诊断、制定和调整药物治疗方案、判断药物治疗效果和不良反应的重要依据,但应注意的是药物可能会对症状和体征产生影响。符合原发病治疗目的的药效作用常可使原发疾病相关的症状和体征得到改善,但非药物治疗目的的药物不良反应、药物相互作用则可使患者出现新的症状和体征,也可能引起、加重或掩盖原发病相关的症状和体征,而药物或其代谢物的颜色等理化性质也会影响症状和体征。这些影响会增加疾病的诊断和治疗的难度,干扰疗效判断和药物不良反应的鉴别,甚至延误治疗和处理。故在临床工作中应注意合理用药并加强药学监护,尽可能避免或减少药物对症状和体征的不利影响,保持高度警惕,及时发现这些影响并作相应处理。 Symptoms and signs are clinically used for diagnosis, differential diagnosis, formulation and adjustment of drug treatment programs to determine the efficacy of drugs and adverse reactions, an important basis, but it should be noted that the drug may have an impact on symptoms and signs. The pharmacodynamic effects that are consistent with the treatment of the primary disease can often improve the symptoms and signs associated with the primary disease, but the adverse drug reactions that are not the purpose of the drug treatment and the drug interactions can lead to new symptoms and signs in the patient, Cause, aggravate or mask the symptoms and signs of the primary disease, and the physical and chemical properties such as the color of the drug or its metabolites also affect the symptoms and signs. These effects increase the difficulty of diagnosis and treatment of diseases, interfere with judgment of efficacy and identification of adverse drug reactions, and even delay treatment and treatment. Therefore, in clinical work should pay attention to the rational use of drugs and strengthen pharmacy care, as far as possible to avoid or reduce the adverse effects of drugs on the symptoms and signs, remain vigilant, timely detection of these effects and make the appropriate treatment.