Leptin rescues neurons from Alzheimer’s disease-related pathways triggered by lipid burden

来源 :阿尔茨海默氏病研究进展(英文) | 被引量 : 0次 | 上传用户：x_schen

【摘要】

：

Adipocyte-derived leptin is a pleiotropic hormone implicated in control of lipid storage and mobilization, bone homeostasis, immune function and neuronal plasti

【作者】

：

Steven J. Greco George Perry J

【机构】

：

Neurotez,Stanford/VAMedicalCenter,UniversityofTexas

【出处】

：

阿尔茨海默氏病研究进展(英文)

【发表日期】

：

2013年1期

【关键词】

：

LEPTIN Cholesterol CERAMIDE AMPK SIRT Alzheimer’s Tau Amyloid-β Leptin Cholester

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Adipocyte-derived leptin is a pleiotropic hormone implicated in control of lipid storage and mobilization, bone homeostasis, immune function and neuronal plasticity. Leptin has been shown to prevent accumulation of extracellular Aβ and hyperphosphorylatio

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