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目的 :观察慢性乙型肝炎 (CHB)患者经 α-干扰素 (IFN- α)抗病毒治疗前后血清中白细胞介素 - 2 (IL- 2 )和可溶性白细胞介素 - 2受体 (s IL- 2 R)水平的变化与乙肝病毒消长之间的关系。方法 :收集治疗前后血清标本 - 2 0℃保存 ,通过 EL ISA法同步检测并与正常人作对照。结果 :IFN- α无效应答组 (n=15 )治疗前血清中 IL- 2水平较有效应答组 (n=10 )和正常组 (n=10 )高 (P<0 .0 1) ;但治疗后则明显下降 ,而有效应答组治疗后则明显升高 ;s IL- 2 R血清水平在 IFN- α有效应答组治疗前明显高于无效应答组和正常组 (P<0 .0 1) ,但治疗后则明显下降 ,虽然无效应答组治疗后略有上升 ,但治疗前后无显著性差异。结论 :IFN- α除本身对 CHB患者体内病毒复制有抑制作用外 ,还可能参与体内免疫调节 ,对病毒复制产生影响。
Objective: To investigate the changes of serum interleukin - 2 (IL - 2) and soluble interleukin - 2 receptor (sIL - 2) levels in patients with chronic hepatitis B (CHB) 2 R) levels and the relationship between the decline of hepatitis B virus. Methods: The serum samples before and after treatment were collected and stored at 20 ℃. The results of EL ISA were compared with those of normal controls. Results: The level of IL-2 in serum before treatment in IFN-α null response group (n = 15) was higher than that in effective response group (n = 10) and normal group (n = 10) , But decreased significantly in the effective response group (P <0.01). The serum level of IL-2R in the effective response group was significantly higher than that in the effective response group and the normal group (P <0.01) But after treatment decreased significantly, although the invalid response group increased slightly after treatment, but no significant difference before and after treatment. CONCLUSION: IFN-α, in addition to its own inhibition of viral replication in patients with CHB, may also be involved in immune regulation in vivo, affecting the virus replication.