比较葡萄糖酸锌、二巯基丁二酸、二巯基丙磺酸钠、依地酸钙钠治疗肝豆状核变性的疗效及其副作用.结果发现二巯基丙磺酸钠组有效率为78%,疗效最佳;二巯基丁二酸组有效率77.4%;葡萄糖酸锌组为70%;依地酸钙钠组为58.3%.葡萄糖酸锌组的副反应发生率25%,对周围血象及肝肾功能影响最小,显著低于其他3组.4种药物中二巯基丙磺酸钠疗效最好,葡萄糖酸锌副作用最少. To compare the efficacy and side effects of zinc gluconate, dimercaptosuccinic acid, sodium dimercaptopropane sulfonate and calcium edetate on the treatment of hepatolenticular degeneration.It was found that the effective rate of sodium dimercaptopropionate group was 78% The best effect was found in the group of dimercaptosuccinic acid (77.4%), gluconate group (70%) and edetate sodium group (58.3%). The incidence of side effects was 25% in zinc gluconate group, The effect of renal function was the smallest, which was significantly lower than the other three groups, among which, sodium dimercaptopropionate had the best effect and zinc gluconate had the least side effects.