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目的通过石榴花提取物(Pomegranate Flower Extract,PFE)对2型糖尿病(T2DM)大鼠空腹血糖(FPG)、血清胰岛素、炎症因子白介素-6(IL-6)和胸腺指数的影响,研究PFE对糖尿病大鼠免疫功能的影响。方法采用高热量饲料加小剂量链脲佐菌素建立实验性2型糖尿病大鼠模型,分别用石榴花提取物100 mg/kg和300 mg/kg治疗4周后,处死大鼠,测定空腹血糖(FPG)和血清胰岛素水平(INS),白介素-6(IL-6)的含量,计算胸腺指数、胰岛素敏感性指数(ISI),推断对T2DM大鼠免疫功能的影响。结果石榴花提取物能显著降低2型糖尿病大鼠的空腹血糖,显著增加ISI。降低血清炎症因子IL-6并提高胸腺指数。结论石榴花提取物可降低2型糖尿病大鼠的空腹血糖,降低血清炎症因子IL-6的含量并提高胸腺指数。
Objective To investigate the effect of PFE on the fasting blood glucose (FPG), serum insulin, interleukin-6 (IL-6) and thymus index in type 2 diabetes mellitus (T2DM) rats by Pomegranate Flower Extract (PFE) Effect of Immune Function in Diabetic Rats. Methods High-calorie diet and low-dose streptozotocin (STZ) were used to establish a rat model of type 2 diabetes mellitus. Rats were sacrificed after treatment with pomegranate extract 100 mg / kg and 300 mg / kg for 4 weeks respectively. The fasting blood glucose (FPG), serum insulin (INS) and interleukin-6 (IL-6) levels were calculated. Thymus index and insulin sensitivity index (ISI) were calculated to evaluate the effect on immune function in T2DM rats. Results Pomegranate extract can significantly reduce fasting blood glucose in type 2 diabetic rats and significantly increase ISI. Lower serum inflammatory cytokine IL-6 and increase thymus index. Conclusion Pomegranate extract can reduce fasting blood glucose in type 2 diabetic rats, decrease serum IL-6 and increase thymus index.