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目的探讨结缔组织病患者肺功能受损的情况及其病理生理原因。方法测定 80例患者的肺功能 ,并与正常对照组进行比较。结果弥散功能显著减低 ,且有显著性差异 (P<0 .0 5 ) ;异常百分率经综合分析自高至低依次为弥散功能为 6 8.7% ,小气道阻塞为 46 .0 % ,肺气肿为 42 .0 % ,通气功能减退为 2 8.7% ,阻塞性通气障碍为 2 6 .2 % ,限制性通气障碍为 2 1.2 % ;相关分析显示一氧化碳弥散量与肺总量呈正相关 (r=0 .6 8,P<0 .0 1)。结论结缔组织病患者的肺功能损害以弥散功能减退为主 ,其次可见小气道阻塞、肺气肿、通气功能减退 ,其肺功能损害的病理生理基础是肺间质受累致肺毛细血管床减少、间质纤维化、小气道阻塞及肺容积的改变
Objective To investigate the pulmonary function impairment in patients with connective tissue disease and its pathophysiological reasons. Methods The lung function of 80 patients was measured and compared with the normal control group. Results Diffusion function was significantly reduced, and there was significant difference (P <0. 05); abnormal percentage by comprehensive analysis of high to low followed by diffuse function was 67.7%, small airway obstruction was 46.0%, emphysema Was 42.0%, the hypofunction of ventilation was 8.72%, the rate of obstructive ventilatory dysfunction was 26.2% and the limit of ventilatory impairment was 2 1.2%. Correlation analysis showed that there was a positive correlation between the amount of carbon monoxide dispersion and total lung volume (r = 0 .6 8, P <0. 0 1). Conclusions Pulmonary dysfunction in patients with connective tissue disease is mainly caused by diffuse dysfunction, followed by small airway obstruction, emphysema and hypofunction. The pathophysiology of pulmonary dysfunction is the decrease of pulmonary capillary bed due to interstitial lung involvement, Interstitial fibrosis, small airway obstruction and lung volume changes