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目的观察盐酸戊乙奎醚注射液对急性有机磷中毒患者恢复时间的影响。方法将92例急性有机磷中毒患者随机分成观察组和对照组各46例。观察组患者采用盐酸戊乙奎醚注射液治疗,对照组患者采用阿托品治疗。对比2组患者的恢复时间、疗效及不良反应。结果观察组患者的临床症状消失时间、胆碱酯酶活性恢复时间及住院时间均显著短于对照组,差异均有统计学意义(P<0.01)。观察组患者的治疗有效率为93.48%明显高于对照组的71.74%,差异有统计学意义(P<0.01)。观察组患者的不良反应发生率为4.35%显著低于对照组的23.91%,差异有统计学意义(P<0.01)。结论盐酸戊乙奎醚注射液能有效缩短急性有机磷中毒患者的恢复时间,提高疗效,减少不良反应,是安全而有效的治疗药物。
Objective To observe the effect of penehyclidine hydrochloride injection on the recovery time of patients with acute organophosphate poisoning. Methods 92 patients with acute organophosphate poisoning were randomly divided into observation group and control group, 46 cases each. Patients in the observation group were treated with Penehyclidine Hydrochloride Injection, and patients in the control group were treated with atropine. The recovery time, efficacy and adverse reactions of two groups were compared. Results The disappearance time of clinical symptoms, recovery time of cholinesterase activity and hospital stay in observation group were significantly shorter than those in control group (P <0.01). The effective rate of treatment in the observation group was 93.48%, which was significantly higher than that in the control group (71.74%), the difference was statistically significant (P <0.01). The incidence of adverse reactions in observation group was significantly lower than that in control group (4.35% vs 23.91%, P <0.01). Conclusion Penehyclidine hydrochloride injection can effectively shorten the recovery time of patients with acute organophosphate poisoning, improve the curative effect and reduce adverse reactions, which is a safe and effective therapeutic drug.