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目的探讨肺硬化性血管瘤患者的临床病理特点。方法对2009年6月至2010年6月收治的12例肺硬化性血管瘤患者进行临床病理特征及免疫组化研究。结果肺硬化性血管瘤有乳头状结构区、实性细胞区、海绵状血管瘤样区及硬化区4种结构,实性区及乳头轴心为形态一致的多角形细胞,乳头表面和血管样腔面为立方状细胞。两种细胞均表达EMA、TTF-1,立方状细胞表达CK-pan,多角形细胞表达vimentin,少数表达CgA、syn、PR、Ki-67。12例均由4种结构混合而成,其中2例以乳头状结构为主,2例以实性区为主。结论 SHL多见于中青年女性,发病率低,易误诊为肺癌。典型的组织形态特征结合TTF-1、EMA、CK、vimentin等免疫组化染色,是诊断和鉴别诊断SHL的主要方法。
Objective To investigate the clinicopathological features of patients with pulmonary sclerosing hemangioma. Methods From June 2009 to June 2010, 12 patients with sclerosing hemangioma were enrolled. The clinicopathological features and immunohistochemistry were studied. Results There were four structures of papillary area, solid cell area, cavernous hemangioma area and sclerotic area in pulmonary sclerosing hemangioma. The solid area and papillary axis were polygonal cells with consistent morphology, Cavity surface is cubic cells. Both cells expressed EMA, TTF-1, CK-pan in cubic cells, vimentin in polygonal cells, few in CgA, syn, PR and Ki-67.12 cases. Cases with papillary structure, two cases of solid-based. Conclusion SHL more common in young women, the incidence is low, easily misdiagnosed as lung cancer. Typical histopathological features combined with immunohistochemical staining of TTF-1, EMA, CK, vimentin, etc. are the main methods for the diagnosis and differential diagnosis of SHL.