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目的评价新疆缺碘地区重点人群(孕妇及哺乳期妇女)有针对性口服碘油丸后的干预的效果。方法利用随机对照的设计进行干预研究,以县为单位将新疆按概率比例规模抽样方法(PPS)抽取30个县随机分为干预组与对照组进行口服碘油丸干预效果的研究。排除无法参加研究的研究对象,最终参与随机干预研究的研究对象有1 020名,其中干预组为402名,对照组为618名,在给予干预组有针对性的口服碘油丸后,分析随机化干预的效果。研究对象纳入调查的标准:30个县(市)的17~50岁,怀孕3个月以内的孕妇、哺乳期妇女,且尿碘水平低于250μg/L。结果在给予干预组有针对性口服碘油丸后,干预组尿碘中位数为206.9μg/L,对照组尿碘中位数为172.2μg/L,经统计检验干预组与对照组的尿碘均数有统计学差别(Z=3.98,P=0.000 1),干预组尿碘均数较对照组高,干预效果明显。结论随机化干预研究提示进行有针对性口服碘油丸后,可以提高孕妇及哺乳期妇女的尿碘水平,本研究可以为碘缺乏重病区实行针对性地口服碘油丸的措施提供依据。
Objective To evaluate the intervention effect of targeted iodized oil pill in key population (pregnant women and lactating women) in areas lacking iodine in Xinjiang. Methods Intervention study was conducted with a randomized controlled design, and 30 counties in Xinjiang were randomly divided into intervention group and control group to study the effect of oral administration of iodized oil pills in Xinjiang by unit of probability proportional sampling method (PPS). Excluding those who could not participate in the study of the object of the study, the final participation of randomized intervention study of 1,020 subjects, of which intervention group was 402, the control group was 618, after giving the intervention group targeted oral iodized oil pills, the analysis of random The effect of intervention. Subjects were included in the survey criteria: 17-50 years old in 30 counties (cities), pregnant women within 3 months of pregnancy, and lactating women with urinary iodine levels below 250 μg / L. Results The median of urinary iodine in the intervention group was 206.9 μg / L after giving the targeted oral iodized oil bolus to the intervention group, and the median of urinary iodine in the control group was 172.2 μg / L. The urine of the intervention group and the control group The average number of iodine was statistically different (Z = 3.98, P = 0.000 1). The mean number of urinary iodine in the intervention group was higher than that in the control group, and the intervention effect was obvious. Conclusions The randomized intervention study suggests that the targeted oral administration of iodized oil can improve urinary iodine levels in pregnant women and lactating women. This study can provide evidence for the implementation of targeted iodized oil pills in iodine deficiency areas.