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超氧化物歧化酶(Superoxide Dismutase,SOD)是体内氧化代谢过程中产生的超氧阴离子(O_2~-)的清除剂。而O_2~-可引发自由基的连锁反应,引起生物膜结构的广泛损伤破坏,与机体内炎症、衰老、肿瘤有密切联系。SOD可催化O_2的歧化反应生成H_2O_2,进一步代谢生成水,从而清除O_2~-,保护机体免受O_2~-的损害。因此,探讨活性氧自由基和SOD代谢在慢性心衰中作用具有重要意义。
Superoxide dismutase (SOD) is a scavenger of superoxide anion (O 2 -) produced in the process of oxidative metabolism in vivo. O_2 ~ - can trigger the chain reaction of free radicals, causing extensive damage to the biofilm structure, which is closely related to the inflammation, aging and tumor in the body. SOD can catalyze the disproportionation reaction of O 2 to generate H 2 O 2 and further metabolize to generate water, thereby clearing O 2 - - and protecting the organism from O 2 - - damage. Therefore, to explore the role of reactive oxygen species and SOD metabolism in chronic heart failure is of great significance.