H抗原是A、B抗原的前身物质,其缺乏影响了A、B抗原的形成,直接导致其血清学表现为O型,如输了O型血液,若患者血清中有抗-H,有发生溶血性输血反应的可能,应引起各科医师的高度关注。现将笔者收集的4例H抗原阴性者血型血清学特点和基因测序结果报告如下。1材料与方法1.1一般资料先证者1,女,38岁;先证2,男,34岁;先证者 H antigen is a precursor of A, B antigen, its lack of impact on the formation of A, B antigen, a direct result of its serological performance of O-type, such as O-type blood loss, if the patient serum anti-H, have occurred Hemolytic transfusion reactions may lead to the attention of all physicians. Now I collected 4 cases of H-negative seropositivity and gene sequencing results reported below. 1 Materials and Methods 1.1 General Information Proof 1, female, 38 years old; first card 2, male, 34 years old; proband