目前各国药典规定的热原检查方法主要是家兔试验法。该法在试验时,常因各种因素的影响,使其准确性降低。我们根据多年从事此项检查的经验,将试验中导致兔温变化的各种因素,采用正交设计方法,系统地进行了试验考察,初步找出了热原试验的最佳方案。用鲎试验法进行阳性、阴性试验证明:本方案能较 At present, the pyrogen test method prescribed by the pharmacopoeias of various countries is mainly the rabbit test method. The law in the test, often due to various factors, to reduce its accuracy. Based on the experience of many years in this inspection, we systematically carried out the experimental investigation based on the various factors that led to the change of rabbit temperature during the experiment. The best solution for the pyrogen test was initially found out. Test with 鲎 positive, negative test proved that: the program can be more