论文部分内容阅读
目的:观察甲地孕酮在治疗晚期非小细胞肺癌(NSCLC)化疗中的辅助治疗作用。方法:治疗组25例给予甲地孕酮联合GP方案[GEM(吉西他滨)+DDP(顺铂)]治疗;对照组25例行单纯GP方案化疗。两组患者均21 d为1个周期,所有患者至少接受4周期治疗。观察两组患者疗效。结果:治疗组患者在提高Karnofsky评分、食欲改善以及在保护骨髓功能和减轻胃肠道反应方面均优于对照组,差异有统计学意义(P<0.05),未见甲地孕酮引起的不良反应。结论:甲地孕酮联合GP方案不良反应轻,患者生活质量得到明显改善。
Objective: To observe the adjuvant therapy of megestrol in the treatment of advanced non-small cell lung cancer (NSCLC) chemotherapy. Methods: 25 cases in the treatment group were given megestrol combined with GP regimen (GEM (gemcitabine) + DDP (cisplatin)]; 25 cases in the control group were given GP regimen alone. Both groups of patients 21 d for a cycle, all patients received at least 4 cycles of treatment. Observed the curative effect of two groups of patients. Results: The patients in the treatment group were superior to the control group in improving the Karnofsky score, improving appetite, and in protecting the bone marrow function and alleviating the gastrointestinal reaction (P <0.05), and no adverse reactions caused by megestrol reaction. Conclusion: The adverse reaction of megestrol combined with GP regimen is mild and the quality of life of patients is significantly improved.