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目的观察心脉通对收缩期高血压患者血清SOD、GSH-PX、CAT及MDA指标变化的影响。方法将80例患者随机分为治疗组及对照组各42例,对照组予以尼索地平治疗,治疗组予以中药心脉通治疗;治疗后运用分光光学计检测治疗前1日及治疗2W、3W及4W后的血清指标,并与23例正常人的血清指标加以比较。结果治疗用药前高血压组与正常对照组比较,高血压组的MDA含量明显升高(P<0.05),而SOD、CAT、GSH-PX指标则显著下降(P<0.05);用心脉通药物治疗后再与正常对照组比较,则MDA呈明显下降(P<0.05),具有非常显著性统计学意义。结论检测SOD、CAT、GSH-PX、MDA指标变化对指导临床用药有着重要的意义,中药心脉通对治疗单纯性收缩期高血压有很好的疗效,有着同尼索地平一样的效果。
Objective To observe the effect of Xinmaitong on the changes of serum SOD, GSH-PX, CAT and MDA in patients with systolic hypertension. Methods Eighty patients were randomly divided into treatment group (n = 42) and control group (n = 42). The control group was treated with nisoldipine. The treatment group was given traditional Chinese medicine Xintimang. After the treatment, spectrophotometer was used to detect the first day of treatment and the treatment of 2W, And 4W after the serum indicators, and 23 normal subjects were compared serum markers. Results Compared with the normal control group, the content of MDA in the hypertension group was significantly increased (P <0.05), while the indexes of SOD, CAT and GSH-PX were significantly decreased (P <0.05) After treatment compared with the normal control group, the MDA was significantly decreased (P <0.05), with a very significant statistical significance. Conclusion Detecting changes of SOD, CAT, GSH-PX and MDA indexes is of great significance to guide the clinical medication. XMT has a good effect on the treatment of simple systolic hypertension and has the same effect as nisoldipine.