E-钙黏素是一肿瘤浸润抑制基因,与肿瘤分化状态有关。近年来发现人类许多恶性上皮肿瘤如食管癌、前列腺癌、肝癌、胃癌等存在E-钙黏素表达下降或缺失。越来越多研究认为,E-钙黏素基因启动子区域CpG岛甲基化是其失活的原因,参与了肿瘤的形成、发生和发展。本文就E-钙黏素基因甲 E-cadherin is a tumor suppressor of invasion, and tumor differentiation status. In recent years, many malignant human epithelial tumors such as esophageal cancer, prostate cancer, liver cancer, gastric cancer, etc. have been found to have decreased or absent E-cadherin expression. More and more studies suggest that CpG island methylation in the promoter region of E-cadherin is the cause of inactivation, which is involved in the formation, development and progression of tumors. In this paper, E-cadherin gene A