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目的观察益肾化瘀汤治疗糖尿病肾病的临床疗效。方法将120例糖尿病肾病患者随机分为治疗组、对照组,各60例。对照组仅予降糖、降压及饮食控制治疗;治疗组口服益肾化瘀汤,同时使用降糖、降压及饮食控制治疗;两组疗程均为90天。观察两组治疗前后临床症状变化情况及空腹血糖、糖化血红蛋白、24 h尿蛋白定量、尿微量蛋白、血尿素氮、血肌酐水平。结果治疗组、对照组总有效率分别为90.0%和73.3%,组间临床疗效差异有统计学意义(P<0.05)。治疗组空腹血糖、24 h尿蛋白定量、血尿素氮、血肌酐水平与本组治疗前比较,差异均有统计学意义(P<0.05);对照组空腹血糖、血尿素氮、血肌酐水平与本组治疗前比较,差异均有统计学意义(P<0.05)。组间比较,24 h尿蛋白定量、尿微量蛋白水平差异有统计学意义(P<0.05)。结论益肾化瘀汤治疗糖尿病肾病疗效良好。
Objective To observe the clinical efficacy of Yishen Huayu Decoction in the treatment of diabetic nephropathy. Methods 120 patients with diabetic nephropathy were randomly divided into treatment group and control group, each with 60 cases. The control group only hypoglycemic, antihypertensive and diet control treatment; the treatment group oral Yishen Huayu Tang, at the same time the use of hypoglycemic, antihypertensive and diet control treatment; two courses of treatment were 90 days. The changes of clinical symptoms and the changes of fasting blood glucose, glycosylated hemoglobin, 24 h urinary protein, urinary microalbuminuria, blood urea nitrogen and serum creatinine were observed before and after treatment. Results The total effective rates in the treatment group and the control group were 90.0% and 73.3%, respectively. There were significant differences in clinical efficacy between the two groups (P <0.05). The fasting blood glucose, 24 h urinary protein, blood urea nitrogen and serum creatinine in the treatment group were significantly different from those before treatment in the treatment group (P <0.05). The levels of fasting blood glucose, blood urea nitrogen, serum creatinine, This group before treatment, the differences were statistically significant (P <0.05). There were significant differences in 24 h urine protein and urine microalbumin levels between groups (P <0.05). Conclusion Yishen Huayu Decoction has a good therapeutic effect on diabetic nephropathy.