,Macrophage amphiregulin-pericyte TGF-β axis: a novel mechanism of the immune system that contribute

来源 :生物化学与生物物理学报(英文版) | 被引量 : 0次 | 上传用户:sdszsh122
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
The immune system plays a vital role in restoring tissue integrity and function upon injury.Wound healing is a highly dynamic process that involves early inflammatory phase,proliferative phase,and finally the maturation phase.Tissue repair begins with the formation of granulation tissue that contains macrophages to play anti-inflammatory roles.Macrophages within the granulation tissue acquire a spectrum of phase-specific phenotypes affecting fibroblast function,including myofibroblast differentiation,myofibroblast proliferation,and extracellular matrix (ECM) remodeling [1].Nevertheless,the underlying mechanism that macrophage contributes to the myofibroblast production during tissue repair remains largely unexplored.
其他文献
1病历摘要女,63岁。既往心脏病史40 a余,40 a前在田间劳动时出现憋闷,休息后可缓解。患者近2个月来间断胸闷、气短伴大汗及肩背部沉重,发作时间长短不等,偶有体位改变后可缓
目的探讨恶性肿瘤并发带状疱疹的临床特点,观察疗效,探讨恶性肿瘤与带状疱疹的关系。方法回顾性分析10例恶性肿瘤合并带状疱疹患者的临床特点、治疗方法及疗效,做分析研究。
期刊
Microbial natural products have always performed a prominent role in the history of drug discovery and development [1].These secondary metabolites have a remark
期刊
RNA-Seq has quickly become the standard method for transcriptomics [1].It is well understood that the quality of the sequencing data highly depends upon the qua
期刊
本文根据2004-01-2010-12武汉市商业职工医院收治的16例诊断为急性ST段抬高型心肌梗死(acute ST elevationmyocardial infarction,ASTEMI)但冠脉造影检查正常的患者作为研究
目的探讨肝内胆管囊腺瘤的CT表现特征,并结合鉴别诊断分析误诊原因,提高本病的影像诊断。方法对收集的9例肝内胆管囊腺瘤进行回顾性分析。结果 9例中有8例呈多房性,1例单房性
Lamprey is the most primitive jawless vertebrates.It is a ‘living fossil’ and ideal model animal for vertebrate origin and evolution study [1-3].In recent yea
期刊
脑梗死后癫痫发生率为10%~14%,在这些患者中很多患者又合并糖尿病。糖尿病并发癫痫较常见,一般出现在低血糖,酮症酸中毒及高渗性昏迷等情况下,临床中非酮症高血糖导致部分运动
Acyl-protein thioesterase 1 (APT1) is considered to be a key enzyme of S-depalmitoylation.Recently,Kathayat et al.[1] revealed the existence of APT1 in mitochon
期刊