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近年来美国用于治疗肉毒中毒的几乎全部是 A、B、E 三价抗毒素,此种产品的每瓶效价各为:7500、5500、8500单位。然而缺乏抗毒素在接受者体内的量、抗毒素中和毒素能力及抗毒素半寿期的研究。本文测定了四个接受三价肉毒抗毒素病人血清中抗毒素的量。四位病人血清抗毒素量几乎没有差别,即使接受不同剂量的抗毒素治疗也是如此。病人血清中发现的 A、B、E 型抗毒素量的高值中和毒素的能力分别超过小鼠半数致死量的1×10~8、9×10~7、6×10~6倍。
In recent years, almost all of the United States used to treat botulism are A, B and E trivalent antitoxins. The titer of each bottle of such products is 7500, 5500 and 8500 units. However, the lack of antitoxin in recipients, the ability of antitoxin to neutralize toxins and antitoxin half-life studies. This article determined the amount of antitoxin in the sera of four patients receiving trivalent botulinum antitoxin. There was almost no difference in the amount of anti-toxin among the four patients, even when treated with different doses of antitoxin. Patients with serum A, B, E-type anti-toxin high value and the ability to neutralize toxins were more than half the lethal dose of mice 1 × 10 ~ 8,9 × 10 ~ 7,6 × 10 ~ 6 times.