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氨基糖甙类是临床上急性肾衰最常见原因之一,对其肾毒性的病理生理已做了深入研究。然而均限于正常动物,与临床上只有病人接受药物有所不同。本实验旨在确定坏死组织病灶的存在是否易引起氨基糖甙类急性肾衰。实验鼠分四组:(1)捆扎约25％肝组织造成组织缺血灶;(2)25％肝切除;(3)假手术。这三组动物术后应用庆大霉素80mg/kg,Bid×2;(4)捆扎25％肝脏但不用庆大霉素。只有部分肝捆扎加庆大霉素治疗的鼠发生急性肾衰,袭现为氮质血症(BUN80±2;肌酐1.63±0.21mg/dl)和肾小管坏死。但均未能
Aminoglycosides are one of the most common causes of acute renal failure clinically, and their pathophysiology of nephrotoxicity has been studied in depth. However, they are all restricted to normal animals, which is different from the clinical practice of patients receiving drugs. The purpose of this experiment was to determine whether the presence of necrotic tissue lesions could cause acute aminoglycoside renal failure. The experimental rats were divided into four groups: (1) about 25% of the liver tissues were bundled into ischemic tissue; (2) 25% of the liver resected; (3) sham operation. Gentamicin 80mg / kg, Bid × 2 were applied after operation in these three groups of animals. (4) 25% strapping of the liver but no gentamicin. Only partial liver bundling plus gentamicin-treated rats developed acute renal failure with evidence of azotemia (BUN 80 ± 2; creatinine 1.63 ± 0.21 mg / dl) and tubular necrosis. But they failed