升阳通瘀经验方剂辨治气陷血瘀证冠心病心绞痛的临床研究

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目的:观察用升阳通瘀经验方剂治疗气陷血瘀证冠心病心绞痛的临床效果。方法92例气陷血瘀证冠心病心绞痛患者随机分为两组,对照组给予硝酸酯类药物、β受体阻滞剂、利尿剂、吸氧等常规西医治疗;治疗组在常规西医治疗基础上给予自拟升阳通瘀经验方剂,两组均以2周为1个疗程,6个疗程后观察两组患者临床有效率;比较两组治疗前后心绞痛的发作次数、持续时间及硝酸甘油用量的变化情况;观察治疗前后心功能的改善情况,并检测血液流变的变化。结果治疗组总有效率明显高于对照组(P<0.05);患者胸闷、气短乏力、自汗、心绞痛等临床症状于治疗后出现不同程度的改善,证候积分与治疗前相比有所降低,治疗组的改善较对照组更突出(P<0.05);治疗组较对照组心绞痛发作次数更少,持续时间更短,硝酸甘油用量患者更少( P<0.05);治疗组心功能改善更明显,左心室舒张末内径(LVDD)、左室射血分数(LVEF)、心肌耗氧量水平较对照组变化更显著(P<0.05);两组血液流变有不同程度的改善,治疗组相关指标改善更突出( P<0.05)。结论升阳通瘀经验方剂能有效改善气陷血瘀证冠心病心绞痛患者的症状,提高心功能,改善血液循环。“,”Abstracts:Objective To observe the clinical efficacy of treating angnia pectoris patients with qi collapse and blood stasis syndrome by usingShengyangtongyudecoction.Methods 92casesofangniapectorispatientswithqicollapseandbloodstasissyndromewererandomly divided into 2 group.The control group was treated with conventional western medicine foundation treatment, such as nitrates, beta blockers, diuretics and oxygen;while the treatment group was treated with Shengyangtongyu decoction,2 weeks for a course, after treating for 6 courses, observe the clinical effect;compare the frequency of attack, the duration of the attack and the change of the dosage of nitroglycerin in the two groups;observe the improvement of heart function;,detect the changes of blood rheology before and after treatment.Results The efficiency in treatment group was higher than thecontrol group (P<0.05);the main clinical symptoms in two groups, such as chest tightness, short-ness of breath, fatigue, spontaneous perspiration and angina were improved clearly compared with before treatment, and the symptom scores went down clearly, the degree of change in treatment group was more pronounced ( P<0.05);the patients’ attack frequency of angina in treatment was less than that of the control group, the duration of angina pectoris was shorter than that of control group, and the nitroglycerin dosage was less than that of control group (P<0.05);the improvement of patients’ cardiac function in the treatment group was better than that of control group , the level change of LVDD, LVEF and myocardial oxygen consumption in treatment group was more obvious than that of control group (P<0.05); the patients’ blood rheology indexes were improved , the degree of change in treatment group was more pro- nounced than that of control group (P<0.05).Conclusion Shengyangtongyu decoction can effectively improve the patients’ clinical symp-toms,improve cardiac function and improve blood circulation.
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