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目的探讨高原地区高血压患者血压升高与血尿酸的关系。方法选择2007年1月至2010年1月在我院内科住院治疗的世居或移居西藏高原或已从西藏退休定居在平原地区的高血压患者134例(高血压病组)。同期来我院体检的世居或移居西藏高原地区的健康者113例作为对照组。247例受试者均空腹12小时以上,于清晨抽取静脉血2~3 ml送检比较。结果高血压病组血尿酸水平显著高于对照组,差异有极显著的统计学意义(P<0.001);高血压病1、2、3级各组血尿酸水平均显著高于对照组,差异有统计学意义(P<0.05),1级患者血尿酸水平显著低于高血压病2级、3级(P<0.001、P<0.05),2级、3级高血压患者血尿酸水平相近,差异无统计学意义(P>0.05);两组男性血尿酸水平均显著高于女性(P<0.05、P<0.001),汉族血尿酸水平均显著高于藏族(均P<0.05)。结论血尿酸增高既是高血压病产生的原因之一,也是高血压病患者代谢紊乱的结果之一,产生的原因主要与血尿酸生成增加和排出减少有关。男性血尿酸水平均高于女性,汉族高于藏族。改善生活方式和饮食习惯,平衡持久的降压治疗,对改善体内代谢、降低血尿酸水平是有益的。
Objective To investigate the relationship between blood pressure and serum uric acid in hypertensive patients in plateau area. Methods From January 2007 to January 2010 in our hospital internal medicine treatment of living or migrating to the Tibetan Plateau or have retired from Tibet to settle in the plain areas of 134 cases of hypertension patients (hypertension group). The same period to our hospital physical examination or migrate to Tibet plateau region 113 healthy subjects as a control group. 247 subjects were fasting for more than 12 hours in the early morning to extract venous blood 2 ~ 3 ml for comparison. Results The level of serum uric acid in hypertension group was significantly higher than that in control group (P <0.001). The levels of serum uric acid in hypertension group 1,2,3 and 6 were significantly higher than those in control group The level of serum uric acid in grade 1 patients was significantly lower than that in patients with grade 2 and 3 hypertension (P <0.001, P <0.05). The level of serum uric acid in patients with grade 2 and 3 hypertension was similar, There was no significant difference between the two groups (P> 0.05). The levels of serum uric acid in both groups were significantly higher than those in females (P <0.05, P <0.001). The levels of serum uric acid in Han were significantly higher than those in Tibetan (P <0.05). Conclusion Increased serum uric acid is not only one of the causes of hypertension, but also one of the metabolic disorders in patients with hypertension. The reasons are mainly related to the increase of blood uric acid and the decrease of excretion. Male blood uric acid levels were higher than women, Han Chinese than Tibetan. Improving lifestyle and eating habits, balancing long-lasting antihypertensive treatment, is beneficial for improving body metabolism and lowering serum uric acid levels.