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随着国家“二孩”政策的开放以及人口老龄化改变,高龄有生育要求的女性越来越多。高龄患者在借助辅助生育技术实现生育目标时,面临卵巢功能下降导致的周期获卵数少等问题,如何选择科学合理的受精方式,提高仅有的卵母细胞受精率,成为目前临床医生关注的热点。本文结合高龄女性卵母细胞发育特点、单精子卵母细胞内注射的应用及其影响,对近年来高龄低反应患者受精方式选择的相关研究进行综述。
With the opening of the national “second child” policy and the aging of population, more and more women are required to have fertility in old age. Older patients in the use of assisted reproductive technology to achieve reproductive goals, the reduction of ovarian function caused by the number of oocytes obtained by the cycle less, how to choose a scientific and rational way of fertilization and improve the fertilization rate of only the oocyte, has become the clinician’s attention Hot spots. In this paper, combined with the characteristics of oocyte development in elderly women, intracytoplasmic sperm injection and its impact on the elderly in recent years, low-response patients with selection of fertilization research are reviewed.