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采用双抗体夹心ＥＬＩＳＡ方法对６４例慢性肝炎患者、４３例肝硬化患者和２８例正常人血清细胞间粘附分子（ＩＣＡＭ－１）、白细胞介素－６（ＩＬ－６）、ＩＬ－８、肿瘤坏死因子α（ＴＮＦ－α）水平进行测定。结果：慢性肝炎及肝硬化患者血清ＩＣＡＭ－１及细胞因子水平均明显高于正常（Ｐ＜０．０１），且病情越重其升高越明显。慢性肝炎重度＞中度＞轻度（Ｐ＜０．０５～０．０１）；肝硬化患者高于慢性肝炎患者；失代偿期肝硬化患者高于代偿期肝炎患者（Ｐ＜０．０５）。提示慢性肝病患者血清ＩＣＡＭ－１及炎症相关性细胞因子水平测定可用于判断病情程度及其预后。
Serum levels of intercellular adhesion molecule-1 (ICAM-1), interleukin-6 (IL-6), IL-8 and IL- Tumor necrosis factor alpha (TNF-alpha) levels were measured. Results: The levels of serum ICAM-1 and cytokines in patients with chronic hepatitis and cirrhosis were significantly higher than those in normal controls (P <0.01). Chronic hepatitis severe> moderate> mild (P <0.05 ~ 0.01); patients with cirrhosis were higher than those with chronic hepatitis; Patients with decompensated cirrhosis were higher than patients with compensated hepatitis (P <0.05 ). It is suggested that the serum level of ICAM-1 and the level of inflammatory cytokines in patients with chronic liver disease can be used to judge the severity and prognosis.