视网膜母细胞瘤(Rb)是人类特有的一种视网膜肿瘤,为了深入研究其发病机制,有必要建立遗传性Rb动物模型。笔者综合分析多个基因工程Rb动物模型的实验结果,简要介绍应用基因工程技术建立Rb动物模型的最新研究进展。认为Rb的发生不仅是Rb1基因的缺失,尚有其他基因的协同作用。 Retinoblastoma (Rb) is a human-specific retinal neoplasm. In order to further study its pathogenesis, it is necessary to establish a genetic Rb animal model. The author comprehensively analyzed the experimental results of a number of genetically engineered Rb animal models and briefly introduced the latest research progress on establishing Rb animal models using genetic engineering techniques. It is thought that the occurrence of Rb is not only the deletion of Rb1 gene, but also the synergy of other genes.