免疫毒素，又称生物导弹，由导向性的载体分子与具有毒性的弹头蛋白进行交联而制备，主要用于治疗肿瘤顽症。近年来，在免疫素素的弹头设计、载体选择及导向策略上都有了很大的发展，其临床应用方面也取得了一定的成绩。本文就其基础研究与临床应用方面的进展做一综述。 Immunotoxin, also known as bio-missile, is prepared by the cross-linking of a targeted carrier molecule with a toxic warhead protein and is mainly used to treat chronic tumor problems. In recent years, there have been great developments in the design, vector selection and orientation strategies of immunonins, and some achievements have also been made in clinical application. This article reviews its progress in basic research and clinical application.