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目的探讨尘肺患者在服用螺旋藻药物前后血清丙二醛(MDA)和超氧化物歧化酶(SOD)的变化。方法用直接硫酸巴比妥酸测定方法及黄嘌呤氧化酶测定方法,对30例Ⅰ期尘肺患者在服用螺旋藻药物治疗前后血清MDA、SOD的含量变化。结果服用螺旋藻药物1个月后的矽肺患者血清MDA含量明显要比不服用螺旋藻的矽肺患者血清MDA含量低(P<0.01)。而血清SOD的活力在服用螺旋藻后要比服用前明显升高(P<0.01)。结论服用螺旋藻药物后,能减轻二氧化硅在肺泡巨噬细胞生物膜的类脂质发生的过氧化反应及产生自由基,能减少机体SOD清除剂的损耗。
Objective To investigate the changes of serum malondialdehyde (MDA) and superoxide dismutase (SOD) in patients with pneumoconiosis before and after taking spirulina drugs. Methods The contents of MDA and SOD in serum of 30 stage Ⅰ patients with pneumoconiosis before and after taking Spirulina drug were measured by direct sulphate barbituric acid assay and xanthine oxidase test. Results Serum MDA levels in patients with silicosis after taking spirulina drug for 1 month were significantly lower than those in patients without silicosis (P <0.01). Serum SOD activity in spirulina after taking was significantly higher than before taking (P <0.01). Conclusion Spirulina drugs can reduce the lipid peroxidation and generate free radicals in the biofilm of alveolar macrophages, which can reduce the loss of SOD scavenger.