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目的:对131I治疗甲状腺功能亢进症常规公式进行改良,提高131I首次治疗甲状腺功能亢进症治愈率,降低早发性甲状腺功能低下发生率。方法:观察131I常规治疗剂量(对照组)与改良131I公式个体化给药方案(治疗组)治疗甲状腺功能亢进症的效果,并进行比较。结果:治疗组、对照组首次痊愈率分别为86.6%,54.9%,早发性甲状腺功能低下发生率分别为4.6%,11.9%,2组比较差异均有统计学意义(P<0.01)。结论:改良131I公式个体化给药方案治疗甲状腺功能亢进可明显提高首次痊愈率,降低早发性甲状腺功能低下发生率。
OBJECTIVE: To improve the conventional formula of 131I in the treatment of hyperthyroidism, and to improve the cure rate of 131I for the first time in treating hyperthyroidism and reduce the incidence of early hypothyroidism. Methods: The effects of 131I conventional treatment dose (control group) and modified 131I formula individualized treatment regimen (treatment group) on hyperthyroidism were observed and compared. Results: The first cure rates of the treatment group and the control group were 86.6% and 54.9%, respectively, and the incidences of early hypothyroidism were 4.6% and 11.9% respectively. There was significant difference between the two groups (P <0.01). Conclusion: The modified 131I formula individualized dosing regimen for the treatment of hyperthyroidism can significantly improve the first cure rate and reduce the incidence of early hypothyroidism.