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目的:观察炎症因子在糖尿病肾病中晚期患者体内的变化规律,综合分析与炎症因子的相关性,以期探索积芎解毒方延缓发展的作用与机理。方法:按纳入标准选择糖尿病肾病(Ⅲ~Ⅴ期)患者60例,再随机分为治疗组30例,对照组30例。对照组给予常规西医治疗,治疗组在此基础上加服积芎解毒方颗粒剂,分别于用药前后检测实验室指标、炎症因子。结果:糖尿病肾病患者炎症因子MCP-1、NF-кB、TLR4、AngⅡ水平异常增高,芎解毒方具有明显下调其水平的作用,经治疗后患者体内血清尿素氮、肌酐水平均下降,说明该药物可以改善糖肾患者的肾功能。结论:糖尿病肾病与炎症因子水平的增高具有一定的相关性。积芎解毒方能下调炎症因子,降低血清尿素氮、肌酐水平水平,较好的改善糖尿病肾病患者的肾功能,机理可能与通过降低炎症反应从而延缓肾功能发展有关。
OBJECTIVE: To observe the changes of inflammatory cytokines in patients with advanced stage of diabetic nephropathy, and to analyze the correlation between them and inflammatory factors in order to explore the role and mechanism of JXXD in delaying development. Methods: According to the inclusion criteria, 60 patients with diabetic nephropathy (stage Ⅲ ~ Ⅴ) were randomly divided into treatment group (n = 30) and control group (n = 30). The control group was given routine western medicine treatment. On the basis of this, the treatment group added Jixiong Jiedu Fang Granule, and the laboratory indexes and inflammatory factors were detected before and after treatment respectively. Results: The levels of inflammatory cytokines MCP-1, NF-кB, TLR4 and AngⅡ in patients with diabetic nephropathy were abnormally increased. The effect of Xiong Jie Du Fang was obviously down-regulated. The levels of serum urea nitrogen and creatinine in patients with diabetic nephropathy decreased after treatment, Can improve renal function in patients with sugar and kidney. Conclusion: Diabetic nephropathy has a certain correlation with the increase of inflammatory cytokines. Jixiong detoxification can reduce inflammatory cytokines, lower serum urea nitrogen, creatinine levels, improve renal function in patients with diabetic nephropathy, the mechanism may be related to the delay of renal function by reducing the inflammatory response.