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2例患者(例1男性,32岁;例2女性,27岁),应用抗结核药物治疗期间肝功能均正常,因尿酸水平升高加用别嘌醇0.1 g,3次/d口服。2周后出现发热、皮疹。实验室检查:例1丙氨酸转氨酶(ALT)1182 U/L,天冬氨酸转氨酶(AST)595 U/L,总胆红素25.9 mmol/L;例2 ALT 1452 U/L,AST 1942 U/L。停用别嘌醇及抗结核药,接受保肝治疗。2例患者肝功能分别于治疗后14、25 d后基本恢复正常。例1继续抗结核治疗,随访4个月肝功能正常。例2因病情稳定停止抗结核治疗。
Two patients (1 male, 32 years old; 2 females, 27 years old) had normal liver function during treatment with anti-TB drugs and allopurinol 0.1 g 3 times daily was given orally due to elevated uric acid levels. 2 weeks after fever, rash. Laboratory tests: Example 1 Alanine aminotransferase (ALT) 1182 U / L, aspartate aminotransferase (AST) 595 U / L, total bilirubin 25.9 mmol / L; Example 2 ALT 1452 U / L, AST 1942 U / L. Disable allopurinol and anti-TB drugs, liver treatment. The liver function of two patients returned to normal after 14 and 25 days of treatment, respectively. Example 1 continue anti-TB treatment, follow-up 4 months normal liver function. Case 2 stopped due to stable condition of anti-TB treatment.