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目的评价沙培林膀胱内灌注预防浅表性膀胱癌术后复发的疗效和安全性。方法对32例浅表性膀胱癌患者行经尿道膀胱肿瘤电切术或膀胱部分切除术,术后定期用沙培林3ku溶于40ml生理盐水中,膀胱内灌注,每周1次连续6周后,改为每月1次连续12个月,每次药物在膀胱内保留2小时。结果所有患者随访3~18个月,无肿瘤复发27例(84.4%),复发5例(15.6%),未见有全身性药物不良反应,仅4例膀胱灌注后出现短时间轻度膀胱刺激症状。结论沙培林膀胱内灌注预防浅表性膀胱癌术后复发疗效满意,病人耐受性好,副作用小。
Objective To evaluate the efficacy and safety of intranasal perfusion of sapirin in preventing postoperative recurrence of superficial bladder cancer. Methods Thirty-two patients with superficial bladder cancer underwent transurethral resection of the bladder tumor or partial resection of the bladder. After surgery, they were dissolved in 40ml of normal saline with 3ml of Sapirin and then intravesical instilled once weekly for 6 weeks , Instead of once a month for 12 consecutive months, each time the drug retained in the bladder for 2 hours. Results All the patients were followed up for 3-18 months. There were 27 cases (84.4%) with no tumor recurrence and 5 cases (15.6%) relapsed. No systemic adverse drug reactions were observed. Only 4 cases with mild bladder irritation after intravesical instillation symptom. Conclusion Spermine intravesical instillation is effective in preventing postoperative recurrence of superficial bladder cancer with good patient tolerance and little side effects.