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[目的]探讨重组人促红细胞生成素(rHuEPO)对慢性肾衰竭(CRF)患者红系及营养状况与生活质量的影响。[方法]对24例CRF患者给予rHuEPO1万IU皮下注射,每周1次,连续8周,在治疗前后分别对红系参数、营养状态和生活质量进行检测,并行自身对照。[结果]患者治疗后2、8周红系指标RBC、Hb、HCT、MCV、MCH、MCHC、Ret均明显升高(P﹤0.05);IRF在2周时显著升高(P﹤0.01)而RDW8周后明显升高(P﹤0.01);营养参数血清白蛋白(ALB)、总蛋白(TP)、转铁蛋白(Tf)治疗后明显增加,差异有统计学意义(P﹤0.05)。生活质量中躯体功能、躯体职能、精力状况、社会功能、疼痛、总的健康状况治疗前后比较差异均有统计学意义(P﹤0.05)。[结论]rHuEPO不仅能改善CRF患者的贫血状态,而且可改善患者的营养状况和生活质量。
[Objective] To investigate the effect of recombinant human erythropoietin (rHuEPO) on erythroid and nutritional status and quality of life in patients with chronic renal failure (CRF). [Methods] Twenty-four patients with CRF were injected subcutaneously with rHuEPO 10,000 IU once a week for 8 weeks. The parameters of erythroid, nutritional status and quality of life were measured before and after treatment, and self-control was performed. [Results] The erythrocyte indices of RBC, Hb, HCT, MCV, MCH, MCHC and Ret were significantly increased (P <0.05) at 2 and 8 weeks after treatment in patients. IRF increased significantly at 2 weeks RDW significantly increased after 8 weeks (P <0.01); The nutritional parameters of serum albumin (ALB), total protein (TP) and transferrin (Tf) increased significantly after treatment, with statistical significance (P <0.05). The quality of life in body function, body function, energy status, social function, pain, general health status before and after treatment were statistically significant differences (P <0.05). [Conclusion] rHuEPO can not only improve the anemia state of CRF patients, but also improve the nutritional status and quality of life of patients.