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以脱镁叶绿酸-a甲酯为起始原料,通过3-位乙烯基与氧化苯甲腈和4-取代氧化苯甲腈的1,3-偶极环加成反应,分别得到3-位异噁唑基取代的二氢卟吩衍生物以及其他形式的加成产物,对其脱镁叶绿酸的E-环结构修饰则转换成相应的二氢卟吩-p_6衍生物;脱镁叶绿酸-a甲酯经空气氧化和重排反应形成了红紫素-18-内酰胺,再与4-取代氧化苯甲腈进行相同的环加成反应,也以理想的产率生成标题化合物.所得新的二氢卟吩衍生物的化学结构均经UV,IR,~1H NMR及元素分析得以证实,并对相应的反应提出可能的反应机理.
Using pheophorbide-a methyl ester as the starting material, 1,3-dipolar cycloaddition reaction of 3-position vinyl with benzoyl peroxide and 4-substituted oxybenzonitrile gave 3- Isoxazolyl-substituted chlorin derivatives and other forms of addition products, the E-ring structural modification of pheophorbide is converted to the corresponding chlorin-p_6 derivatives; magnesium removal The chlorogenic acid-a methyl ester was subjected to air oxidation and rearrangement to form the purpurin-18-lactam, which was then subjected to the same cycloaddition with 4-substituted oxybenzonitrile to generate the title in the desired yield The chemical structures of the new chlorin derivatives were confirmed by UV, IR, 1H NMR and elemental analysis, and the possible reaction mechanism was proposed for the corresponding reaction.