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目的研究地榆升白片防治结直肠癌FOLFOX(奥沙利铂+亚叶酸钙+5-氟尿嘧啶)方案化疗后免疫功能下降的作用。方法 72例结直肠癌患者随机分为对照组和实验组,各36例,两组患者均接受FOLFOX方案化疗。化疗开始后,实验组患者口服地榆升白片;对照组患者不预防用药。观察两组患者外周血中性粒细胞、CD3+T细胞和CD4+T细胞的变化。结果两组患者的外周血中性粒细胞、CD3+T细胞和CD4+T细胞化疗过程中均下降,其中对照组患者下降较实验组明显(P<0.05)。结论地榆升白片有防治FOLFOX化疗后中性粒细胞、CD3+T细胞和CD4+T细胞下降的作用,保护了患者的免疫功能。
Objective To study the effect of decoction of Diyu Shengbai tablet on the prevention and treatment of colorectal cancer FOLFOX (oxaliplatin + leucovorin + 5-fluorouracil) chemotherapy. Methods 72 cases of colorectal cancer patients were randomly divided into control group and experimental group, each 36 cases, both groups received FOLFOX regimen chemotherapy. After the start of chemotherapy, patients in the experimental group orally rose white tablets; patients in the control group did not prevent medication. The changes of neutrophil, CD3 + T cells and CD4 + T cells in peripheral blood of two groups were observed. Results The levels of neutrophil, CD3 + T cells and CD4 + T cells in peripheral blood of patients in both groups decreased during the chemotherapy, and the decrease in the control group was more significant than that in the experimental group (P <0.05). Conclusion Di Yu Sheng Baipian can prevent the decrease of neutrophil, CD3 + T cells and CD4 + T cells after FOLFOX chemotherapy and protect the immune function of patients.