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目的:探讨自拟方辅助西药治疗原发性高血压肝阳偏亢、肝风上扰证临床效果。方法:研究对象选取该院2014年6月—2015年6月收治原发性高血压肝阳偏亢、肝风上扰证患者共70例,采用随机抽签法分为对照组(35例)和治疗组(35例),分别采用单纯西药治疗和在此基础上加用自拟方辅助治疗;比较两组患者血压控制达标率,治疗前后中医证候积分,动态血压、超声心动图指标水平及不良反应发生率等。结果:治疗组患者血压控制达标率显著高于对照组,差异有统计学意义(P<0.05);治疗组患者治疗后中医证候积分均显著低于对照组、治疗前,差异有统计学意义(P<0.05);治疗组患者治疗后动态血压指标水平均显著低于对照组、治疗前,差异有统计学意义(P<0.05);治疗组患者治疗后LVM和LVMI水平均显著低于对照组、治疗前,差异有统计学意义(P<0.05);两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论:自拟方辅助西药治疗原发性高血压肝阳偏亢、肝风上扰证可有效缓解临床症状体征,控制24 h动态血压水平,逆转左心室肥厚进程,且未增加不良发应发生风险。
Objective: To investigate the clinical efficacy of self-made prescription western medicine in treating hyperthyroidism with liver-yang hyperactivity and liver wind disturbance. Methods: The subjects were selected from the hospital from June 2014 to June 2015, 70 cases of hypertensive liver cirrhosis, liver wind disturbance patients were randomly divided into control group (35 cases) and The treatment group (n = 35) was treated with western medicine alone and combined with self-prepared adjuvant therapy. The blood pressure control compliance rate, TCM syndrome score, ambulatory blood pressure and echocardiography before and after treatment were compared between the two groups Adverse reaction rate and so on. Results: The compliance rate of blood pressure control in treatment group was significantly higher than that in control group (P <0.05). The scores of TCM syndromes in treatment group were significantly lower than those in control group after treatment, and the difference was statistically significant (P <0.05). The levels of ambulatory blood pressure after treatment in the treatment group were significantly lower than those in the control group (P <0.05), and the levels of LVM and LVMI in the treatment group were significantly lower than those in the control group Group, before treatment, the difference was statistically significant (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion: It is effective to relieve the symptoms of liver-yang hyperactivity in patients with essential hypertension and liver wind disturbance by self-made prescription western medicine, to control the ambulatory blood pressure level at 24 hours, reverse the course of left ventricular hypertrophy, and not increase the incidence of adverse reactions risk.