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目的观察纳洛酮联合氨茶碱治疗早产儿原发性呼吸暂停的疗效。方法2002-01—2006-01于鞍山市中心医院就诊的原发性呼吸暂停早产儿74例,分为治疗组40例和对照组34例。在常规治疗基础上,两组均常规应用氨茶碱注射液治疗呼吸暂停,首次负荷量5mg/kg,12h后予维持量2mg/kg,每12h给药1次,稀释后静滴;治疗组加用纳洛酮注射液,首次负荷量0·1mg/kg,静推,1h后按0·01mg/(kg·h)的速度经微量输液泵持续静脉注射,每日总量不超过0·4mg/kg。结果治疗组显效率和总有效率分别为67·5%(27/40)和95·0%(38/40),对照组分别为44·1%(15/34)和73·5%(25/34)。两组显效率比较差异有显著性意义(χ2=4·09,P<0·05),总有效率比较差异有非常显著性意义(χ2=6·69,P<0·01)。结论纳洛酮联合氨茶碱治疗早产儿原发性呼吸暂停疗效优于单用氨茶碱。
Objective To observe the efficacy of naloxone combined with aminophylline in the treatment of premature infants with primary apnea. Methods A total of 74 patients with primary apnea and preterm infants admitted to Anshan Central Hospital from January 2002 to June 2006 were divided into treatment group (n = 40) and control group (n = 34). On the basis of conventional treatment, both groups were routinely treated with aminophylline injection for apnea, the first load of 5mg / kg, 12h after the maintenance dose of 2mg / kg, administered once every 12h, diluted intravenous; treatment group Plus naloxone injection, the first load of 0 · 1mg / kg, static push, 1h after 0 · 01mg / (kg · h) by micro infusion pump continuous intravenous injection, the total daily dose of not more than 0 · 4 mg / kg. Results The effective rate and total effective rate in the treatment group were 67.5% (27/40) and 95.0% (38/40) respectively, while those in the control group were 44.1% (15/34) and 73.5% 25/34). Significant difference between the two groups was significant (χ2 = 4.09, P <0.05), the total effective rate was significantly different (χ2 = 6 · 69, P <0.01). Conclusion Naloxone combined with aminophylline is superior to aminophylline in the treatment of primary apnea in preterm infants.