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目的:探讨分析降钙素原(PCT)联合C反应蛋白(CRP)检测对新生儿败血症早期诊断及病情评估的临床意义。方法:选取2012年2月至2014年2月我院新生儿科收治的败血症患者30例与非败血症患者30例。将败血症患者设为实验组,非败血症患者设为对照组。同时采用化学发光免疫法和散射比浊法分别对这两组新生儿血清PCT与血清C反应蛋白进行检测,一周后对比检测结果,并得出结论。结果:经观察,试验组患者的血清PCT与血清CRP(22.94±8.33)ng/m L、(36.81±11.20)mg/L明显高于对照组(3.10±2.61)ng/m L,(5.82±3.40)mg/L,差异有统计学意义,p<0.05,具有可比性。试验组患者恢复期血清PCT(1.0±0.8)ng/ml与CRP(3.2±1.5)mg/l均较初期明显下降,比较有统计学意义,p<0.05。结论:降钙素原(PCT)联合C反应蛋白(CRP)检测对新生儿败血症早期诊断及病情评估方面具有特异性强,灵敏度高的特点,有助于新生儿败血症病情早期诊断与治疗,值得进行进一步拓展探索与推广应用。
Objective: To investigate the clinical significance of early detection and assessment of neonatal sepsis by analyzing the combination of procalcitonin (PCT) and C-reactive protein (CRP). Methods: Thirty patients with sepsis and 30 patients with non-sepsis were selected from neonatal department of our hospital from February 2012 to February 2014. The sepsis patients as the experimental group, non-sepsis patients as the control group. At the same time, chemiluminescence immunoassay and nephelometry were used to detect serum PCT and serum C-reactive protein in the two groups respectively. The results of the tests were compared one week later and the conclusion was drawn. Results: The serum PCT and serum CRP in the test group (22.94 ± 8.33 ng / m L, 36.81 ± 11.20 mg / L were significantly higher than those in the control group (3.10 ± 2.61 ng / m L, 5.82 ± 3.40) mg / L, the difference was statistically significant, p <0.05, comparable. The serum PCT (1.0 ± 0.8) ng / ml and CRP (3.2 ± 1.5) mg / l in convalescent phase of experimental group were significantly lower than those of initial phase, which were statistically significant (p <0.05). CONCLUSION: The combination of procalcitonin (PCT) and C-reactive protein (CRP) has the characteristics of high specificity and sensitivity in the early diagnosis and assessment of neonatal sepsis, which is helpful for the early diagnosis and treatment of neonatal sepsis. To further explore and promote the use of.