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目的 研究足月危重新生儿抗凝和纤溶系统的变化。方法 采用ELISA法和免疫浊度法测定危重组 2 7例、非危重组 18例和健康组 15例足月新生儿的血浆蛋白C(PC)、总蛋白S(TPS)、抗凝血酶Ⅲ (AT -Ⅲ )、D -二聚体 (D -D)、血管性假血友病因子 (vWF)。结果 足月危重新生儿血浆PC、TPS、AT -Ⅲ低于对照组 ,D -D、vWF明显高于对照组。结论 足月危重新生儿存在抗凝、纤溶系统的激活及血管内皮细胞损伤 ,它们是发现早期DIC的敏感指标。
Objective To study the changes of anticoagulant and fibrinolytic system in critically ill newborns at term. Methods The levels of plasma protein C (PC), total protein S (TPS), antithrombin Ⅲ (AT-III), D-dimer (D-D), von Willebrand factor (vWF). Results The plasma levels of PC, TPS and AT-Ⅲ in critically ill newborn infants at term were lower than those in control group, and the levels of D-D and vWF were significantly higher than those in control group. Conclusion There are anticoagulant and fibrinolytic system activation and vascular endothelial cell injury in critically ill newborns at term. They are sensitive indicators for detecting early DIC.