目的 :探讨阻塞性睡眠呼吸暂停综合征 (OSAS)患者C反应蛋白 (CRP)及纤溶活性的变化情况。方法 :选取经多导睡眠图 (PSG)确诊且未经治疗并排除其他疾病的OSAS患者 32例为OSAS组 ,30例PSG检查正常者为对照组 ,分别测定两组患者血浆超敏CRP(hsCRP)水平及血浆组织型纤溶酶原激活物 (t PA)、纤溶酶原激活抑制物 1(PAI 1)水平。结果 :OSAS组与对照组相比血浆hsCRP水平、PAI 1活性明显升高 ,t PA活性明显下降 (均P <0 .0 1) ,且OSAS越严重 ,血浆hsCRP升高越明显。结论 :OSAS患者hsCRP水平升高、纤溶活性降低 ,且血浆hsCRP水平与OSAS严重程度有关。 Objective: To investigate the changes of C-reactive protein (CRP) and fibrinolytic activity in patients with obstructive sleep apnea syndrome (OSAS). Methods: Thirty-two OSAS patients diagnosed by polysomnography (PSG) and untreated and excluded from other diseases were selected as OSAS group and 30 PSG-normal controls as control group. Plasma hsCRP ) Levels and plasma levels of tissue plasminogen activator (t PA) and plasminogen activator inhibitor 1 (PAI 1). Results: Compared with the control group, the levels of hsCRP, PAI1 and t PA in the OSAS group were significantly lower (all P <0.01), and the more severe the OSAS and the more obvious the hsCRP in the plasma. Conclusion: The hsCRP level and the fibrinolytic activity of OSAS patients are decreased, and the level of plasma hsCRP is related to the severity of OSAS.