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目的:观察探讨太旨黄特型绍兴黄酒对骨质疏松症大鼠的影响及其作用机制。方法:大鼠维甲酸灌胃建骨质疏松模型,70只健康雌性Wistar大鼠随机分为空白对照组、模型对照组、普通黄酒对照组、太旨黄纯药物组、太旨黄低剂量组、太旨黄中剂量组和太旨黄高剂量组7组,每组10只。分别给予相应药物,每天1次,连续灌胃90 d。酶比色法检测血清碱性磷酸酶(ALP),抗酒石酸酸性磷酸酶(StrACP);检测大鼠双侧股骨骨密度(BMD),骨矿含量(BMC)。HE染色,观察骨组织病理形态学。结果:与普通黄酒组比较,太旨黄各组有显著性差异(P<0.05)。结论:太旨黄特型绍兴黄酒对骨质疏松症有一定的治疗作用。
Objective: To observe the effect of Tai Xuan Huang Shaoxing rice wine on osteoporosis rats and its mechanism. Methods: A rat model of osteoporosis was established by intraperitoneal injection of retinoic acid. 70 healthy female Wistar rats were randomly divided into blank control group, model control group, common rice wine control group, TaiZhihuangchun drug group, TaiZhihuang low dose group Too too yellow medium dose group and Tai Xuan Huang high dose group 7, each group 10. Respectively given the corresponding drugs, 1 day, continuous gavage 90 d. Serum alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (StrACP) were detected by enzyme colorimetric assay. Bone mineral density (BMD) and bone mineral density (BMC) were measured. HE staining, bone histopathology was observed. Results: Compared with the common rice wine group, there were significant differences in each group (P <0.05). Conclusions: Too yellow type Shaoxing rice wine has a certain therapeutic effect on osteoporosis.