至今对Sjogren综合征的治疗尚不满意。曾有人用免疫抑制剂治疗,但此制剂通常对慢性及良性过程的疾病能产生副作用,对Sjogren综合征的眼干燥(干燥性角膜结膜炎)症,通常局部可用人工泪液及/或软接触镜进行治疗,但眼部症状很少能得到解除。作者提出用溴苄环己胺(必嗽平,Bromhexine)能增加支气管的分泌,减少其粘稠度,曾被用于治疗慢性支气管炎,但其机理尚不明了。作者用此药治疗伴有干燥性支气管炎的Sjogren综合征患者,发现其眼及口腔干燥亦获得明显缓解,停药又复发,再用又好转。因而用溴苄环己胺及安慰剂来治疗Sjogren综合征,观察它对泪腺及唾液腺分泌的影响有何不同。病人及方法:分低剂量与高剂量两组,都依次进行交叉双盲试验,以同等数目的病人在一个时期内随机抽样,每一次试验时间为两周给予溴苄环己胺治疗,另两周用安慰剂。第一组(低剂量组)口服溴苄环己胺8mg,一天三次;第二组 So far the treatment of Sjogren syndrome is not satisfied. It has been treated with an immunosuppressive agent, but this agent usually has side effects on chronic and benign disease. It is usually applied to artificial eye drops and / or soft contact lenses for Sjogren’s Syndrome (dry keratoconjunctivitis) Treatment, but rarely get rid of eye symptoms. The authors propose that treatment with bromombest cyclohexylamine (Bromhexine) increases bronchial secretion and reduces its viscosity and has been used to treat chronic bronchitis, but the mechanism is not known. The authors used this drug to treat patients with Sjogren’s syndrome with dry bronchitis and found that their eyes and mouth were also significantly relieved of dryness, withdrawal and relapse, reuse and improvement. Therefore, with benzalkonium and placebo to treat Sjogren’s syndrome, to observe its secretion of lacrimal and salivary glands What is the difference. Patients and methods: sub-low-dose and high-dose two groups, followed by cross-blind double-blind test to the same number of patients in a random sampling period, each test period was given two weeks of benzylbromide treatment, the other two Weekly with placebo. The first group (low-dose group) orally bromomethylbenzidine 8mg, three times a day; the second group